Accession Number:

AD0777539

Title:

(1) Pathogenesis, Detection, Prevention and Treatment of Infectious Diseases of Military Importance. (2) Human Leukoxyte Migration Inhibition: An Assay for Endotoxemia. (3) Mechanisms of Endotoxin Tolerance. IX. Effect of Early Exchange Transfusion on Endotoxin Lethality

Descriptive Note:

Annual rept. for 1973

Corporate Author:

MARYLAND UNIV BALTIMORE SCHOOL OF MEDICINE

Report Date:

1974-02-25

Pagination or Media Count:

50.0

Abstract:

The Division of Infectious Diseases of the University of Maryland School of Medicine continues to maintain a volunteer research ward at the Maryland House of Correction, Jessup, Maryland. The purpose of this facility has been to serve as a base for investigations in volunteers of various uniquely human infectious diseases. These studies have been aimed primarily at the evaluation of various vaccines. In recent years the effort has been directed at enteric infections of military importance. Quantitative measurements of effectiveness of oral typhoid and shigella vaccines have been carried out. In addition, attempts have been made to uncover the significance of pathogenesis of and host resistance to infection with the presumed viral agent of winter vomiting disease, enterotoxigenic E. coli and penetrating E. coli. Availability of these human models has allowed for cooperative research projects to explore the role of endotoxin in infectious diseases, and to attempt to define mechanisms of immunity, i.e., cellular versus humoral. The status of these studies is presented in the report.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE