Mechanisms of Oxygen Toxicity at the Cellular Level.
Annual rept. 1 Jan-31 Dec 73,
MISSOURI UNIV COLUMBIA
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The most significant finding has been the demonstration that even five minute exposures to oxygen at four atmospheres produces a severe, but reversible upon removal from hyperoxia, inhibition of active transport of glucose, using Escherichia coli as a model cell system. Experimental data is so far consistent with the current operating theory that a site in membrane transport is the primary target in acute oxygen toxicity at the cell level. The inhibition of transport apparently is not due to lack of energy ATP for transport, nor to oxidative destruction of the membrane, but the true mechanism is unknown. Modified author abstract