Utility of Serum Protein-Bound Neutral Hexoses and L-Fucose for Estimation of Malignant Tumor Extension and Evaluation of Efficacy of Therapy
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Pagination or Media Count:
A method is employed which permits correction for the influence of the neutral hexoses galactose and mannose on the apparent concentration of protein-bound L-fucose as estimated by the Dische-Shettles CyR3 reaction. The values thus obtained, together with the serum concentrations of neutral hexoses, were evaluated in a series of patients, 109 of whom had confirmed diagnoses of cancer. While these two parameters, protein-bound neutral hexoses and protein-bound fucose, were not by themselves sufficient for differential diagnostic application, excellent correlation for presurgical estimation of tumor extension or activity and postsurgical evaluation of efficacy of treatment was achieved.
- Medicine and Medical Research