DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click
HERE to register or log in.
Accession Number:
AD0777032
Title:
Bone Marrow Response of Beagles to Fractionated Doses of Mixed Gamma-Neutron Radiation
Descriptive Note:
Scientific rept.
Corporate Author:
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Report Date:
1973-09-01
Pagination or Media Count:
24.0
Abstract:
Male beagles were bilaterally exposed to mixed gamma-neutron radiation from the AFRRI-TRIGA reactor. The dose rate was 20 radsminute for all irradiations and midline tissue doses were 215 rads, 225 rads and 240 rads. At each dose approximately one-half of the animals received a single irradiation while the others were given one-fourth the dose each day for 4 consecutive days. The objective of this study was to determine if doses in the median lethal range delivered in four equal fractions at 24-hour intervals were more lethal and more damaging to survival-limiting hematopoietic cell renewal systems than similar unfractionated doses. Single irradiations were the more lethal, first evident at 225 rads and increasing markedly in effectiveness at 240 rads. Radiation- induced changes in bone marrow cellularity were similar after single and fractionated irradiations. Modified author abstract
Distribution Statement:
APPROVED FOR PUBLIC RELEASE