Accession Number:

AD0777032

Title:

Bone Marrow Response of Beagles to Fractionated Doses of Mixed Gamma-Neutron Radiation

Descriptive Note:

Scientific rept.

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

• West, J. E.
• Mitchell, F. A.
• Jones, S. R.
• Witz, J.

Report Date:

1973-09-01

Pagination or Media Count:

24.0

Abstract:

Male beagles were bilaterally exposed to mixed gamma-neutron radiation from the AFRRI-TRIGA reactor. The dose rate was 20 radsminute for all irradiations and midline tissue doses were 215 rads, 225 rads and 240 rads. At each dose approximately one-half of the animals received a single irradiation while the others were given one-fourth the dose each day for 4 consecutive days. The objective of this study was to determine if doses in the median lethal range delivered in four equal fractions at 24-hour intervals were more lethal and more damaging to survival-limiting hematopoietic cell renewal systems than similar unfractionated doses. Single irradiations were the more lethal, first evident at 225 rads and increasing markedly in effectiveness at 240 rads. Radiation- induced changes in bone marrow cellularity were similar after single and fractionated irradiations. Modified author abstract

Descriptors:

• *BONE MARROW
• *RADIATION EFFECTS
• DOGS
• DOSE RATE
• EXPERIMENTAL DATA
• GAMMA RAYS
• LABORATORY ANIMALS
• LETHALITY
• RADIATION DOSAGE
• SUBLETHAL DOSAGE

Subject Categories:

• Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE