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Bone Marrow Response of Beagles to Fractionated Doses of Mixed Gamma-Neutron Radiation
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Male beagles were bilaterally exposed to mixed gamma-neutron radiation from the AFRRI-TRIGA reactor. The dose rate was 20 radsminute for all irradiations and midline tissue doses were 215 rads, 225 rads and 240 rads. At each dose approximately one-half of the animals received a single irradiation while the others were given one-fourth the dose each day for 4 consecutive days. The objective of this study was to determine if doses in the median lethal range delivered in four equal fractions at 24-hour intervals were more lethal and more damaging to survival-limiting hematopoietic cell renewal systems than similar unfractionated doses. Single irradiations were the more lethal, first evident at 225 rads and increasing markedly in effectiveness at 240 rads. Radiation- induced changes in bone marrow cellularity were similar after single and fractionated irradiations. Modified author abstract
APPROVED FOR PUBLIC RELEASE