Accession Number:

AD0777016

Title:

Effects of 5-Fluorouracil on Astrocyte Density in the Rat Spinal Cord Dorsal Funiculi after Stab-Wound Lesion.

Descriptive Note:

Annual rept. no. 1, 1 Jun 72-31 May 73,

Corporate Author:

NORTHERN ARIZONA UNIV FLAGSTAFF DEPT OF BIOLOGICAL SCIENCE

Personal Author(s):

Report Date:

1974-01-23

Pagination or Media Count:

10.0

Abstract:

Lesions of both groups contained moderate densities of astrocytes. The average density in the 5-FU treated group was less than that of the controls by 12.6 at the 95 confidence level therefore, the chemotherapy reduced the cell density. Cell migration into the lesion is a possible explanation for the relatively small reduction in astrocyte density. With the present state of knowledge, 5-FU chemotherapy is not warranted to facilitate CNS nerve regeneration. Modified author abstract

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE