Stimulation of Protein Synthesis in Normal and Tumor Cells by Agents Modifying the Cell Surface,
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
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The report discusses the study of the intensity of protein synthesis in cells of various origin both malignant and normal, by the inclusion of C14 of amino acids in the acid-insoluble fraction. For agents modifying the cell surface, several substances having little in common were chosen inactivated Sendai parainfluenza virus complex nucleoprotein, DEAE-dextran polysaccharide containing diethylaminoethyl groups with postive charge, dimethylsulfoxide organic solvent of simple structure-DMSO, and Tween 80 incomplete detergent containing hydrocarbon chains. As a result of tests run in the present study, it has been established that the agents used raise the rate of protein synthesis in intact cells.