Some Patterns Observed in the Interferon Effect
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD FORT DETRICK
Pagination or Media Count:
The authors found that the level of cell resistance resulting from the effects of interferon depends upon the concentration of the drug and the period consumed in administration, and also upon the multiplicty of the infection which is present. Resistance was first noted 1-2 hours following administration of interferon, following which it reached a maximum by the 5th-6th hours, remaining at a constant level indefinitely as long as interferon continued present in the culture fluid. For maximum effect, however, the interferon should be in contact with the cells previously. When the latter precaution was observed, the culture cells showed complete protection from the after-effects of the virus.