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Effect of Certain Antimetabolites and of Chloramphenicol on Conjugation of E. coli K-12,
FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO
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There is major interest in studying the role of processes of transfer of genetic information in bacteria -- conjugation, transformation, and transduction -- in the appearance and propagation of antibiotic-resistant forms of microorganisms. Many researchers have established that by means of the above genetic processes it is possible to transform strains of certain types of bacteria which are sensitive to antibiotics into antibiotic-resistant organisms. The authors studied the effect of chloramphenicol, 5-bromouracil 5-BU, and 8-azaguanine 8-AG on the conjugation of E. coli K-12 on the transfer of genetic markers from the donor to the recipient.
APPROVED FOR PUBLIC RELEASE