Changes in Red Cell P50 and Survival in Stored and Transfused ACD Dog Blood.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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Blood stored in acid-citrate dextrose ACD for varying time periods was studied for effect on survival and oxygen transport. The units were transfused in 50 ml volumes so that each unit was paired with one recipient being the original donor, and the other a compatible subject. Survival values determined 24 hours after transfusion showed gradual decline with length of storage. A shift to the left in the oxygen dissociation curve, indicated by a lower P50 value, was found to correlate with time of storage. After transfusion, the immediate effect was a similar decrease in the P50 however, the value did not fall below the normal range until after 35 days of storage. The change in P50 was not as marked as seen in human studies, and may be related to the amount of transfusion being less than 10 of the estimated blood volume. Author
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