Accession Number:

AD0775796

Title:

A Comparative Study of Human and Monkey ('Macaca irus') Fibrinogen Degradation Products.

Descriptive Note:

Interim rept.,

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1973-09-27

Pagination or Media Count:

15.0

Abstract:

Immunochemical, physical, and anticoagulant properties of human and monkey Macaca irus fibrinogen degradation products FDPs were compared by immunoelectrophoresis, Sephadex G-200 gel filtration, and anticoagulant assay. Both species demonstrated a high degree of similarity in the properties and sequence of generation of FDPs derived from in vitro plasmin digestion of highly purified fibrinogen. The results of this study should permit a closer analogy to be drawn between the pathogenic mechanisms of disseminated intravascular coagulation occurring experimentally in monkeys and clinically in humans. Author

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE