A Comparative Study of Human and Monkey ('Macaca irus') Fibrinogen Degradation Products.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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Immunochemical, physical, and anticoagulant properties of human and monkey Macaca irus fibrinogen degradation products FDPs were compared by immunoelectrophoresis, Sephadex G-200 gel filtration, and anticoagulant assay. Both species demonstrated a high degree of similarity in the properties and sequence of generation of FDPs derived from in vitro plasmin digestion of highly purified fibrinogen. The results of this study should permit a closer analogy to be drawn between the pathogenic mechanisms of disseminated intravascular coagulation occurring experimentally in monkeys and clinically in humans. Author