Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells.
Final technical rept. Dec 72-Nov 73,
ISTITUTO DI EMATOLOGIA GENOA (ITALY)
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A sensitive in vitro method has been set up which measures the stimulation of the hexose monophosphate shunt HMS in normal and glucose-6-phosphate dehydrogenase G6PD deficient red blood cells. It has been used to measure and compare the stimulation produced by methylene blue, primaquine, sulphalene, fanasil, DFD and the experimental drug WZB 08271. These drugs stimulate the HMS in normal red cells but are unable to do so in G6PD deficient cells. In view of these results it is presumed that drugs capable of stimulating the HMS in normal red cells would cause lysis of G6PD deficient red cells in vivo. This prediction has been confirmed in studies using chromium labelled G6PD-deficient red cells in vivo. Author