Accession Number:

AD0775339

Title:

Genetic Control of the Tendency to Tolerance Circumvention,

Descriptive Note:

Corporate Author:

DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)

Personal Author(s):

Report Date:

1973-04-25

Pagination or Media Count:

7.0

Abstract:

Random bred rabbits were injected with human serum albumin HA at birth to induce tolerance to HA. Tolerant animals were then immunized with a p-azobenzenesulfonic acid derivative of human albumin HA-D31. A proportion of these animals, 42, 2764 responded with the production of antibody to HA-D31 TCR-responders. Matings were carried out between TCR-responders and between TCR-nonresponders, and the offspring were subjected to the same procedures as their parents. Selective breeding of TCR-responders produced 70 1217 responders after two generations. Selective breeding of TCR-nonresponders produced only TCR-nonresponders after the third generation. Fourth generation offspring of TCR-nonresponders, which were not injected with HA at birth, produced an antibody response to HA-D31. The genetic control of responsiveness to HA-D31 in HA-tolerant rabbits is polygenic and autosomal. Modified author abstract

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE