Kallikrein, Kinin and Cell Proliferation,
NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGY
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The Kallikrein-Kinin system may have a previously unforeseen role in the initiation of cell proliferation and tissue regeneration. The injection of a pancreatic Kallikrein into rats causes a marked stimulation of DNA synthesis and mitosis in the bone marrow and thymus. This mitogenic action appears to be calcium dependent and is probably indirect through the liberation of kinins. The feasibility of a mediation by kinins is provided by the fact that bradykinin strongly stimulates DNA synthesis and mitosis in suspensions of thymic lymphoblasts, an action which, like that of Kallikrein in the animal, is calcium dependent. It is believed that Kallikrein and its kinin products facilitate the mitogenic action of calcium itself. This is discussed in relation to the known effects of calcium and the control of mitogenesis.
- Anatomy and Physiology