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Accession Number:
AD0774271
Title:
Chemotherapy of Rodent Malaria Drug Action against Exo-Erythrocytic Stages and Drug Resistant Strains,
Descriptive Note:
Corporate Author:
LIVERPOOL SCHOOL OF TROPICAL MEDICINE (ENGLAND) DEPT OF PARASITOLOGY
Report Date:
1973-10-01
Pagination or Media Count:
27.0
Abstract:
Work on the rate of development of resistance to drugs taken singly and in mixtures shows the need for preserving the activity of new anti-malarials by using them therapeutically only in appropriate combinations. Work has continued on the mode of action of antimalarials. A common type of intramolecular hydrogen bond has been noted among compounds with chloroquine-like activity and a new compound has been found to have greater inhibitory activity than quinine on chloroquine-induced haemozoin clumping. Metabolic changes during the plasmodial life cycle have been confirmed in studies of glucose metabolism and cell enzymes. Taxonomic work based on typing of isoenzymes in different plasmodial strains has led to the curious observation that a derived strain of P.berghei contains a different isoenzyme from the parent strain. Other taxonomic relationships have been derived from DNA hybridization experiments, including demonstration of the wide divergence of P.chabaudi and P.vinokei from the P.berghei complex. Modified author abstract
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
