Accession Number:

AD0773950

Title:

Depression of the Lecithin-Cholesterol Acyltransferase Reaction in Vitamin E-Deficient Monkeys,

Descriptive Note:

Corporate Author:

CHILDREN'S HOSPITAL MEDICAL CENTER BOSTON MASS DEPT OF NEUROLOGY

Personal Author(s):

• Mickel,Hubert S.
• Hill,Penelope L.
• Hayes,K. C.

Report Date:

1974-02-06

Pagination or Media Count:

18.0

Abstract:

Vitamin E deficiency in two species of monkeys reduced the esterification of cholesterol by the plasma lecithin-cholesterol acyltransferase reaction. The reduction was greatest in animals fed a diet rich in polyunsaturated fat and stripped of vitamin E. Concomitant to this in vitro measure was a depression in the concentration of circulating polyunsaturated fatty acid cholesteryl esters. Since the plasma lecithin-cholesterol acyltransferase reaction has been shown to be dependent upon sulfhydryl groups on the enzyme, it is proposed that the observed reduction in esterification of cholesterol by plasma from vitamin E-deficient monkeys is due to alteration of these sulfhydryl sites. A similar reduction in the plasma lecithin-cholesterol acyltransferase reaction has been shown to occur during exposure in vivo to a pure oxygen atmosphere, a condition predisposing to lipid peroxidation. Author

Descriptors:

• *VITAMIN E
• *CHOLESTEROL
• BIOCHEMISTRY
• FATTY ACIDS
• OXYGEN
• MONKEYS
• IN VITRO ANALYSIS
• LIPIDS
• LABORATORY ANIMALS
• DEFICIENCIES
• NUTRITION
• OXIDATION REDUCTION REACTIONS
• CHOLESTERYL ESTERS

Subject Categories:

• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE