Autoantibodies and Tuberculin Hypersensitivity of Leukocytes in Silicosis and Silicotuberculosis
FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSONAFB OH
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In recent years interest has steadily grown in regard to immunological processes during silicosis and silicotuberculosis. In the present report the results are given from an investigation of antipulmonary autoantibodies in 150 patients with silicosis and silicotuberculosis. In another series of investigations on 80 patients with silicosis and silicotuberculosis the author determined the hemagglutinating pulmonary autoantibodies by means of induced hemagglutination in the Boyden method M. I. Kitayev, 1967. The titer of this type of autoantibodies usually corresponded to the severity of the process taking place in the lungs. The appearance of complement-fixing autoantibodies preceded in time the synthesis of agglutination pulmonary autoantibodies. It follows from this that the organism responds to the pathological effect of silica initially by intensification of the synthesis of complement-fixing autoantibodies, and only following further progression of the disease process develops agglutination pulmonary autoantibodies.
- Medicine and Medical Research