Inheritance of Responsiveness of Tolerant Animals to a Cross-Reacting Antigen.
DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)
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Random-bred rabbits were rendered tolerant to human serum albumin HA by neonatal injections. Starting at 44 days of age, the rabbits were injected i.v. with para-azobenzenesulfonic acid human albumin HA-D31. Animals which made an antibody response TCR-responders were mated with each other, as were animals which failed to make an antibody response TCR-nonresponders. TCR-nonresponsiveness was found to breed true after three generations of selective matings. TCR-responsiveness did not appear to be correlated with tolerance duration or with any of the allotypic specificities Al,2,3, controlled at the Aa locus. There were no complement-deficient animals among TCR-responders nor among TCR-nonresponders. There was a slightly lower responsiveness to HA-D31 of TCR-nonresponders which were not injected at birth than of unselected animals. Author
- Medicine and Medical Research