The Role of the Sympathetic Nervous System during Exposure to Altitude in Rats.
DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)
Pagination or Media Count:
Since the role of increased noradrenaline NA output during exposure to 5,500 m is not clear, a study was carried out to determine whether increased NA secretion is essential for survival at 5,500 m. To this end rats were treated with guanethidine sulphate during exposure to 5,500 m for two weeks. Guanethidine decreases the release of NA from postganglionic fibres without inhibiting adrenaline A secretion. The exposure conditions were selected as representing a tolerable altitude stress for Sprague-Dawley rats and an exposure period during which body weight changes indicate a degree of acclimation takes place.
- Stress Physiology