Accession Number:

AD0773709

Title:

The Role of the Sympathetic Nervous System during Exposure to Altitude in Rats.

Descriptive Note:

Research paper,

Corporate Author:

DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)

Personal Author(s):

Report Date:

1972-11-06

Pagination or Media Count:

9.0

Abstract:

Since the role of increased noradrenaline NA output during exposure to 5,500 m is not clear, a study was carried out to determine whether increased NA secretion is essential for survival at 5,500 m. To this end rats were treated with guanethidine sulphate during exposure to 5,500 m for two weeks. Guanethidine decreases the release of NA from postganglionic fibres without inhibiting adrenaline A secretion. The exposure conditions were selected as representing a tolerable altitude stress for Sprague-Dawley rats and an exposure period during which body weight changes indicate a degree of acclimation takes place.

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE