Accession Number:

AD0773679

Title:

Failure of Methylprednisolone to Protect Lead-Sensitized Rats against Endotoxin

Descriptive Note:

Medical research progress rept. no. 1,

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

• Jones, Robert B.
• Wise, James L.
• Kiesow, Lutz A.

Report Date:

1973-06-27

Pagination or Media Count:

6.0

Abstract:

The administration of lead acetate PbAc2 sensitizes both rats and subhuman primates to minute amounts of bacterial endotoxin. The mechanism of this sensitization has not been defined, although it has been suggested that alterations in either the degradation of endotoxin, or in carbohydrate metabolism, may be important. Glucocorticoids are demonstrably effective in protecting normal animals against endotoxin. The purpose of the present investigation was to determine if this was also the case in lead-sensitized animals.

Descriptors:

• *TOXINS AND ANTITOXINS
• *LEAD(METAL)
• *CORTICOSTEROID AGENTS
• EXPERIMENTAL DATA
• SENSITIVITY
• IMMUNOLOGY
• LABORATORY ANIMALS
• INFECTIOUS DISEASES
• BACTERIAL DISEASES

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE