Accession Number:

AD0773521

Title:

The Obtaining of Bacterial Allergens by the Alkaline-Extraction Method and the Investigating of their Physico-Chemical Properties

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OH

Personal Author(s):

• Runova, V. F.
• Gavrilenkova, V. Yu.

Report Date:

1974-01-07

Pagination or Media Count:

14.0

Abstract:

A common method of obtaining allergens from bacteria of the group of particularly dangerous infections and of certain representatives of the enteric family is suggested. The method consists in the extraction from microbial cells of alkali-soluble components, their precipitation with acid, dialysis and lyophilization. The protein part of the allergens mainly contained the fraction with a high molecular weight. Thermal treatment of certain allergens tularemic and typhoid was accompanied by the rupture of the bond in the protein molecule, and the separation of fractions with a lesser molecular weight some retained their specific activity.

Descriptors:

• *ANTIGENS
• USSR
• BACTERIA
• PROTEINS
• PRECIPITATION
• EXTRACTION
• LYOPHILIZATION
• DIALYSIS
• ALLERGIC DISEASES
• DIAGNOSTIC AGENTS
• ANTIBODIES
• TRANSLATIONS
• IMMUNOLOGY
• INFECTIOUS DISEASES

Subject Categories:

• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE