A Study of Antibodies and Delayed-Type Skin Reactions to Certain Antigens of Group A Streptococcus in Experimental Animals,
FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO
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It is known that such illnesses as rheumatism, scarlet fever, chronic tonsillitis and erysipelas can result from manifested delayed-type hypersensitivity DTH to the antigens of streptococcus. This is confirmed by the delayed-type skin reactions developing in response to the intradermal injection of the following preparations M-substance, streptokinase, and thermostable fraction obtained from the group A streptococcus. For these diseases as for a number of other infections tuberculosis, brucellosis and others the preservation, sometimes for a number of years, of DTH in the absence of skin reactions of the delayed type is characteristic. The aim of this work was to clarify the following problem does the delayed-type hypersensitivity develop to the antigens of such preparations of streptococcus as the thermostable fraction, M-substance, proteinase, and erythrogenic toxin during the test on animals sensitized with a culture of streptococcus how long does this state last and to what types of immunoglobulins do the antibodies belong.