'In vivo' Role of 'Pseudomonas aeruginosa' Toxins and Host Response
Annual rept. no. 6, 1 Mar 1971-31 Dec 1973
WAYNE STATE UNIV DETROIT MI DEPT OF IMMUNOLOGY AND MICROBIOLOGY
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Current studies indicated that mice receiving either sub-cutaneous or intradermal injections of viable P. aeruginosa cells exhibited systemic infections after several days. The primary target organs appeared to be the kidneys and lungs. Administration of an equal number of dead cells did not kill the mice although approximately 30 of the animals exhibited black necrotic lesions similar in appearance to ecthyma gangrenosum. Attempts to establish pulmonary infections in mice receiving per-oral administration of P. aeruginosa directly into the lungs was unsuccessful. However, per-oral administration of viable cells into the stomach of mice resulted in fatal systemic infections. Chronic systemic infections of rabbits were established in order to study the sequence of events leading to severe kidney damage. Renal lesions were detected by the 5th to 7th day post-infection along with progressive azotemia.