A Safe and Convenient Preparation of Isopropyl Methylphosphonylated Acetylcholinesterase.
Technical rept. Nov 71-Jan 72,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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Isopropyl methylphosphonylated acetylcholinesterase is conveniently and safely prepared by the reaction of acetylcholinesterase with isopropyl m-nitrophenyl methylphosphonate in the presence of fluoride ion. This alternative to the conventional pathway using neat and highly toxic isopropyl methylphosphonofluoridate Sarin offers the combined advantages of the esters lower toxicity, ready preparation and purification, and convenience of storage and use. Modified author abstract