The Influence of 3,5-Diethylhydantoin upon Survival During Acute and Chronic Hypoxia
Technical Report,01 Aug 1972,30 Nov 1972
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX BROOKS AFB
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The median survival times of rats decompressed within five minutes to a barometric pressure of 160 mm Hg 33.5 mm Hg PO2 were significantly increased P less than .05 and P less than .02 in two groups of 15 rats each pretreated with 150 mgkg body wt 3,5-diethylhydantoin DH rats pretreated with 50 mgkg of the drug did not differ from controls. Maximum swimming times of 15 rats exposed to a PO2 of 77 mm Hg and a water temperature of 35C tended to be longer following pretreatment with 50 mgkg DH P less than .10. Sixteen of 20 saline-injected controls survived 11 days of continuous exposure to a PO2 ranging from 37 to 49 mm Hg, compared with 10 of 20 animals treated daily with 50 mgkg and 7 of 20 treated with 150 mgkg DH. The drug-treated animals showed more abnormal pathology than controls. It was concluded that although DH treatment may result in an increase in survival time during acute hypoxia, its apparent toxicity with repeated use in a hypoxic environment precludes its consideration in U.S. Air Force operations.