Sensitizing Activity of the Diphtherial Toxoid Components
FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSONAFB OH
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Immunization with diphtherial toxoid often causes increased sensitivity which is manifested by repeated injections of this preparation. The diphtherial preparations used in practice are a complex mixture of heterogeneous components with respect to the antigenic and physicochemical properties of the components. In examining the extensive literature pertaining to the so-called sensitizing activity of diphtherial toxoid the authors did not find any data dealing with the relative participation of various components of this preparation during the development of increased sensitivity to it. As is known, during the purification of the vaccine preparation, researchers strive to eliminate the ballast impurities in order to increase the immunogenic property and decrease the allergen property of the vaccine.