Effect of Adrenalectomy of Antibody-Forming Cell Production in Animals with a Delayed Type of Hypersensitivity,
FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO
Pagination or Media Count:
The present research has studied the effect of a bilateral adrenalectomy on the formation of cells which form an antibody to the corpuscular antigen sheep erythrocytes in guinea pigs with a delayed type of hypersensitivity HDT to human serum albumin HSA. The following conclusions were drawn for guinea pigs which have received an adrenalectomy and have been sensitized by human serum albumin in a complete Freunds adjuvant, participation of the regional lymph nodes is prevalent in antibody formation. The adrenalectomy led to a decrease in the absolute and relative number of antibody-forming cells in the lymph nodes and spleen of the animals. When the adrenals were removed it was obvious that the mechanism which regulates the intensity of proliferation of the lymphoid fiber had been destroyed.
- Anatomy and Physiology