The Antiviral Action of Ribonuclease
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD FORT DETRICK
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With the use of a model of the virus of Venezuelan equine encephalomyelitis, the inhibiting effect of a preparation of pancreatic ribonuclease on the accumulation and infectious and hemagglutinating activity of the virus, and interferon production in chicken embryo fibroblast culture were determined. Statistical processing confirmed a high degree of correlation in the suppression of all three types of activity. The mechanism of virus-inhibiting action of ribonuclease is discussed. The article includes two tables, two illustrations and a bibliography of 16 titles.