Antibody Response to Repeated Transfusions in Compatible Canine Recipients
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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Several apparent transfusion reactions were observed in a group of experiments involving multiple nonautologous transfusions in dogs. Prior to the transfusions, crossmatches between donor and recipient were performed, which were compatible in most of the dogs. The canine grouping system formulated by Swisher and Young was used to group most of the dogs. Red cell survivals were determined using 51Cr. A rapid loss of erythrocyte radioactivity after transfusion was considered to be evidence of incompatibility. Efforts to determine the source of the incompatibility suggested that the present canine blood group system does not provide sufficient knowledge of the factors involved. The incompatible reactions also suggested the presence of other antigens not defined by Swisher and Youngs system. The use of multiple transfusions in dog experiments--in which results depend upon red cell findings- -may cause confusion because of unsuspected blood incompatibility reactions.
- Medicine and Medical Research