Rapid Disappearance of Radiochromium-Labeled Erythrocytes Immediately After Transfusion in Dogs.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
Pagination or Media Count:
Canine recipients received transfusions of fresh autologous or homologous cells stored for varying periods of time. These cells had been labeled with 51Cr and transfused at a controlled rate within the same time frame. Radioactivity was measured serially during the 20 min after transfusion and then daily. All subjects showed an initial rapid decrease in radioactivity in the first 20 min, which was significantly more rapid with stored cells. Follow-up radioactivity after this point was curvilinear with the daily decrease having a similar slope for fresh and stored cells. The initial loss could not be correlated with length of storage. At the 24-hr point, the percentage of cells remaining in circulation was lower the longer the blood had been stored. The initial loss did not seem to be from blood incompatibility, but appeared to have been from some common pathological mechanism independent of the storage effect. Canine erythrocytes have been found to be more fragile than human red cells, and the initial loss may have been from the adverse effects of collection or the labelling procedure. Subsequent decrease in radioactivity followed the pattern observed in human subjects and indicated the effects of storage. Author
- Medicine and Medical Research