Naturally Occurring Immune-Complex Glomerulonephritis in Cynomolgus Monkeys (Macaca irus). I. Light, Immunofluorescence, and Electron Microscopic Studies.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
Pagination or Media Count:
Light, immunofluorescence, and electron microscopic studies were carried out on renal biopsies from 32 randomly selected adult cynomolgus monkeys Macaca irus. Histopathology was limited to glomeruli and consisted of mild to moderate segmental increases in mesangial cells, mesangial matrix, andor glomerular basement membrane GBM thickness in 40 of the animals. Granular deposits of IgM were present in the mesangium and along the GBM in 72 of the monkeys, whereas IgG, Clg, C4 and C3 were detected in approximately 30. Those monkeys with the heaviest IgM deposition were found to have decreased serum levels of C3, IgM, and IgA. Follow-up biopsies over a period of three to 11 months revealed that the disease process was persistent yet nonprogressive. No correlation with age or sex was noted. All animals examined were clinically healthy, had normal renal function, and generally showed only mild protein-uria. This is the first documented occurrence of spontaneous immune-complex glomerulonephritis in a large monkey colony. It appears to be a persistent disease which does not progress to renal insufficiency and which may serve as an investigative model for mild, nonprogressive forms of human glomerulonephritis. Author
- Animal Husbandry and Veterinary Medicine
- Medicine and Medical Research