Accession Number:

AD0770459

Title:

Secondary Evaluation of Potential Antimalarial Agents.

Descriptive Note:

Final rept. 15 Jul 65-30 Sep 73,

Corporate Author:

IIT RESEARCH INST CHICAGO ILL

Personal Author(s):

• King,Maurice E.
• Schneider,Morris D.
• Shefner,Alan M.

Report Date:

1973-09-30

Pagination or Media Count:

63.0

Abstract:

Test systems were developed and used for screening a number of drugs against normal and drug-resistant blood-induced Plasmodium Berghei infections in mice and Plasmodium gallinaceum infections in chicks. A colony of Aedes aegypti was established to provide infective sporozoite for suppressive testing against Plasmodium gallinaceum a colony of Aedes. stephensi was setup for prophylactic and therapeutic screening against Plasmodium berghei yoelli. The characteristics of plasmodia cryopreserved in liquid nitrogen were investigated. Techniques were developed whereby plasmodia could be stored for long periods without adverse effects on the viability, virulence or drug-resistant properties of malarial strains. Author

Descriptors:

• *ANTIMALARIALS
• CHEMOTHERAPEUTIC AGENTS
• PLASMODIUM
• PARASITIC DISEASES
• AEDES
• LIFE CYCLES
• INFECTIOUS DISEASES
• DRUGS
• PHARMACOLOGY
• LABORATORY ANIMALS

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE