Accession Number:

AD0770365

Title:

CS: A Study of Carcinogenicity

Descriptive Note:

Technical rept.

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s):

• McNamara, Bernard P.
• Renne, Roger A.
• Rozmiarek, Harry
• Fore, Duane F.
• Owens, Edmund J.

Report Date:

1973-11-01

Pagination or Media Count:

20.0

Abstract:

A study of the carcinogenicity of 0-chlorobenzilidenemalononitrile CS in animals is reported. The question of carcinogenicity arose because CS has been described as an alkylating agent and some alkylating agents are carcinogens. The study showed no significant increase of lung tumors in AJ strain mice or Sprague-Dawley-Wister rats from exposure to CS to Cts of 50 and 500 mg mincu m daily for 20 days 5 days a week for four weeks. Exposure concentrations were about 21 mgcu m. Total Cts were, thus, 1.000 and 10,000 mg mincu m. Such a dose would not increase the incidence of tumors by more than 5 if an extremely large sample of animals were dosed. A rioter in the open would not be expected to recieve a Ct of greater than 10 mg mincu m and perhaps 1.0 to 2.5 mg mincu m on the average. Chronic exposure to very low concentrations in an industrial situation could be of greater concern. The data indicate that CS is not a potent carcinogen.

Descriptors:

• *TOXICITY
• *CARCINOGENS
• *CS AGENTS
• NEOPLASMS
• DOSAGE
• LUNG
• MICE
• RESPIRATION
• BIOASSAY

Subject Categories:

• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE