Myocardial Substrate Utilization in Dogs Following Endotoxin Administration
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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Changes of myocardial substrate utilization have been studied in dogs under pentobarbital anesthesia following the administration of E. coli endotoxin. Mycocardial substrate utilization under control conditions at two hours, and again at three to four hours following endotoxin mean arterial blood pressure, heart rate, and arterial pH were decreased while myocardial blood flow did not change. Arterial lactate increased greatly, free fatty acids did not change, glucose and O2 decreased. Myocardial uptake and oxidation of free fatty acids were greatly diminished and lactate uptake markedly elevated both periods following endotoxin. While under control conditions more than 70 of the energy utilization of the myocardium was derived from FFA, and about 30 lactate, following the administration of endotoxin the contribution of FFA to myocardial energy following the administration of endotoxin the contribution of FFA to myocardial energy utilization was greatly diminished and that of lactate was elevated. Thus a shift in utilization of substrates was observed favoring lactate and diminishing the contribution of FFA.
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