Myocardial Performance in Splanchnic Arterial Occlusion Shock.
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY DEPT OF PHYSIOLOGY AND BIOPHYSICS
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The adverse combined effects of mesenteric ischemia and the subsequently precipitated lethal shock following restoration of mesenteric blood flow have implicated direct or indirect roles of the heart in the pathogenesis of shock. The present experiments were carried out to assay the role of the heart in splanchnic arterial occlusion SAO shock. Studies were designed to evaluate the combined effects of SAO shock and diminished coronary perfusion pressure on the performance of a stressed heart. Experiments were carried out on isolated hearts exchanging blood with an intact dog subjected to two hours of splanchnic arterial occlusion. Release of the occlusion did not result in any measurable detrimental effect on the heart Left ventricular end diastolic pressure and cardiac power were maintained in the normal range at mean aortic pressures afterloads between 34-125 mm Hg al all times during the post-occlusion period. DPdt was elevated, possible as a result of increased coronary blood flow and decreased coronary vascular resistance. Modified author abstract
- Anatomy and Physiology
- Medicine and Medical Research