Effects of Coronary Perfusion Pressure on Myocardial Performance During Endotoxin Shock.
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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The cardiopulmonary bypass preparation was utilized in dogs to evaluate the effect of coronary perfusion on myocardial performance in endotoxin shock. Isometric cardiac performance measured by intra-ventricular balloon distention revealed consistently better length-tension curves and pressure work in shocked dogs with high coronary perfusion than in dogs with low coronary perfusion. Results support the view that adequate coronary perfusion may be the most essential determinant of preservation of myocardial function in endotoxin shock and confirm the absence of a circulating myocardial depressant factor. Author
- Anatomy and Physiology
- Medicine and Medical Research