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Effect of Endotoxin on Myocardial Performance
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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The effect of endotoxin on the heart is obscure, and results have been controversial. The purpose of the study was to determine if there is a direct detrimental action of endotoxin on cardiac tissue. An isolated heart and ventilated lungs removed from a donor dog were perfused with venous blood from an intact heparinized animal. An LD90 injection of E. coli endotoxin was intravenously administered to the dog. Results indicate that endotoxin has no early detrimental effect on myocardial performance. Oxygen uptake and left ventricular contractile force were maintained at pre-endotoxin values or increased above control in the presence of severe systemic hypotension in the dog. Left ventricular end diastolic pressure was not elevated in any experiment, but ordinarily decreased after endotoxin. Coronary blood flow progressively increased, and vascular resistance significantly fell.
APPROVED FOR PUBLIC RELEASE