Anti-Lymphocyte Antibodies: Specifically Purified Anti-Thymocyte Antibody as an Immunosuppressive Agent in Human and Rhesus Transplants.
Final technical rept. Sep-Oct 73,
MEDICAL RESEARCH FOUNDATION OF OREGON PORTLAND
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To further isolate the immunosuppressive fraction of antithymocyte antibody, the mouse skin graft system has been developed to test subfractions. The technique of Billingham is used to skin graft between the AJ-C3H strains of mice. Antimouse thymocyte sera has been prepared and a dosage schedule selected and tested. The initial stage of a toxicity experiment has been performed. The authors prepared a toxic sera by hyperimmunization and then selected out the suppressive fraction with an adsorbent. Sheep ATS does not become toxic for mice on hyperimmunization. The whole blood mixed lymphocyte system has been developed in the rhesus monkey. Obtained were high levels of reactivity which had not previously been possible. Modified author abstract
- Medicine and Medical Research