Accession Number:

AD0768950

Title:

Orale Immunisierung mit Nichtvermehrungsfaehigen Mikroorganismen oder ihren Antigenen. 11. Mitteilung: Wirksamkeit von Kombinationsimpfstoffen aus Enterobakteriazeen-Vollantigen im Maeuseschutztest (Oral Immunization with Non-Living Microorganisms or Their Antigens. 11.),

Descriptive Note:

Corporate Author:

ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)

Report Date:

1970-03-16

Pagination or Media Count:

22.0

Abstract:

NMRI-mice are immunised orally on 10 subsequent days with heatinactivated complete antigens from Enterobacteriaceae 3-5 min100C using an esophageal sound. Ten days after the last oral vaccination the animals are infected intraperitoneally. The protective action is estimated by the mortality rate. Four combined vaccines are tested for comparison purposes with the monovalent specific vaccination one bivalent vaccine consisting of S. schwarzengrund and E. coli 2380 O111B4H12, one trivalent vaccine consisting of S. typhi murium, Sh. flexneri 2a and E. coli 2380, one quintvalent vaccine under addition of S. schwarzengrund and S. blockley and one vaccine consisting of 16 different antigens 10 Salmonellae, 4 Shigellae and 2 dyspepsia coli strains. The combined vaccines showed better effectiveness than expected. The combined vaccine of 16 antigens did also show better effectiveness than vaccination with 116 of the monovalent vaccine. All differences in the mortality of combined vaccinated and unvaccinated mice are statistically significant. Modified author abstract

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE