Accession Number:

AD0768949

Title:

Orale Immunisierung mit Nichtvermehrungsfaehigen Mikroorganiemen Oder Ihren Antigenen. 10. Mitteilung: Serologische Primaer- und Sekundaerantwort nach Oraler Impfung mit S. Typhi Murium-Vollantigen im Vergleichenden Tierexperiment (Oral Immunisation with Inactivated Microorganisms or Their Antigens. 10),

Descriptive Note:

Corporate Author:

ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)

Personal Author(s):

Report Date:

1969-11-05

Pagination or Media Count:

17.0

Abstract:

Oral vaccination with heat-inactivated S. typhi murium bacteria does hardly induce increases in the hemagglutinating antibodies in the white mouse. Only after homologous, oral infection, there will occur a strong booster reaction. The duration of the immunological reactivity is very long. Guinea pigs give other reactions to the same oral vaccination than mice. In these animals the HAT-values increase heavily after primary immunisation and remain at medium level over 240 days. Similar to the guinea pigs rabbits show good increase in the HAT after primary vaccination. Very young calves show again other reactions. After oral vaccination, similar to mice, hemagglutinating antibodies are hardly produced. After oral infection with virulent S. typhi murium bacteria there occurs a typical booster reaction. Following subcutaneous vaccination the antibody curve takes a reverse course. Good HAT-values are observed in primary reaction , however, after oral infection any booster reaction fails to appear. Modified author abstract

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE