Mechanisms of Oral Immunization with Inactivated Microorganisms,
ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)
Pagination or Media Count:
An orally introduced antigen will, due to paracellular persorption through the epithelium of the small intestine enter in the lymph and then into the blood. These antigens in the circulation can be evidence for some time. On the other hand the antigen is secreted from the circulation through the mucosa of the respiratory and digestive tracts. Because of the secretion and persorption a circulation of the antigen is established. To an antigen orally introduced the cells of the gut are evidencing a primary reaction. The presence of circulating antibodies is probably a secondary response, especially after a subsequent homologous infection. Evidence reagins resulting from orally introduced antigens are probably responsible for the protective effect towards an infection, achieved after an orally administered antigen. The latter is postulated from results of experiments on animal and man. The important practical advantage of oral immunization is discussed.