Accession Number:

AD0768941

Title:

Einfluss von Carcinogenen Nitrosaminen auf die Induktion der Serin-Dehydratase in der Rattenleber (The Influence of Carcinogenice Nitrosamines on the Induction of Serine Dehydratase in the Rat Liver),

Descriptive Note:

Corporate Author:

ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)

Personal Author(s):

• Jennissen,H.
• Hoshino,J.
• Kroeger,H.

Report Date:

1970-12-07

Pagination or Media Count:

8.0

Abstract:

Nitrosamine-associated carcinogensis disturbs the regulatory systems for various enzymes in the liver of rats. In the present paper, the influences of N-nitroso morpholine and diethyl-nitrosamine on the induction of serine dehydratase by casein hydrolysate and fasting were studied. Induction by casein remains unaffected by these two substances. Under diethyl-nitrosamine diet, induction by fasting is considerably increased, whereas N-nitroso morpholine shows no effect. By using glucose it was established, that the increased enzyme activity subsequent to induction by fasting is a consequence of an increased enzyme synthesis. Author

Descriptors:

• (*NITROSO COMPOUNDS
• *CANCER)
• (*ENZYMES
• NITROSO COMPOUNDS)
• AMINES
• LIVER
• RATS
• WEST GERMANY

Subject Categories:

• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE