Accession Number:
AD0768941
Title:
Einfluss von Carcinogenen Nitrosaminen auf die Induktion der Serin-Dehydratase in der Rattenleber (The Influence of Carcinogenice Nitrosamines on the Induction of Serine Dehydratase in the Rat Liver),
Descriptive Note:
Corporate Author:
ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)
Personal Author(s):
Report Date:
1970-12-07
Pagination or Media Count:
8.0
Abstract:
Nitrosamine-associated carcinogensis disturbs the regulatory systems for various enzymes in the liver of rats. In the present paper, the influences of N-nitroso morpholine and diethyl-nitrosamine on the induction of serine dehydratase by casein hydrolysate and fasting were studied. Induction by casein remains unaffected by these two substances. Under diethyl-nitrosamine diet, induction by fasting is considerably increased, whereas N-nitroso morpholine shows no effect. By using glucose it was established, that the increased enzyme activity subsequent to induction by fasting is a consequence of an increased enzyme synthesis. Author
Descriptors:
Subject Categories:
- Biochemistry