Accession Number:

AD0768940

Title:

Immunogenitaet Mycobakterieller Zellwaende Gegen Experimentelle Aerogene Tuberkuloseinfektion der Maus (Immunogenicity of Mycobacterial Cell Walls against Experimental Airborne Tuberculosis),

Descriptive Note:

Corporate Author:

ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)

Report Date:

1969-01-01

Pagination or Media Count:

23.0

Abstract:

As in cade of other bacteria so far tested the immunogenic factors of Mycobacteria also seem to be located in or upon the cell wall. The immunogenic potency of mycobacterial cell wall-vaccines has been examined in parallel with viable BCG-vaccine in mice against airborne infection with virulent tubercle bacilli. Mycobacterial cell walls afford protection only when administered by the intravenous route as an oil-in water-emulsion. So far, only mineral oils and the synthetic hydrocarbon 7-hexyloctadecane were found suitable to function as carriers for the cell wall material. In this test system the degree of immunity obtained was in parallel with a considerable proliferation of macrophages and lymphocytes in lungs and spleens of the mice. Modified author abstract

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE