Baroreceptor Reflex Response to Phenylephrine and Carotid Occlusion in Monkeys Receiving 1000 Rads Cobalt-60
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Nine conscious monkeys received phenylephrine and carotid occlusion test of baroreflex function before and after 1000 rads Cobalt-60 exposure dose rate 170 radsmin.. During the early postradiation minutes, concomitantly with hypotension and tachycardia, both baroreflex tests revealed depressed sensitivity diminished blood pressure and heart rate changes. After 8-15 minutes postradiation, the phenylephrine, but not the occlusion test demonstrated a reversal to significant baroreceptor hypersensitivity which persisted 24 hours or more. No failure of the baroreflex mechanisms was suggested.