Accession Number:

AD0768815

Title:

Vergleichende Untersuchung der Intestinalantikeorper nach Oraler oder Intraperitonealer Immunisierung von Naeusen mit Hammelerythrozyten (Comparative Investigation on Intestinal Antibodies Following Oral or Intraperitoneal Immunization of Mice with Sheep Erythrozytes),

Descriptive Note:

Corporate Author:

ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)

Report Date:

1970-11-19

Pagination or Media Count:

11.0

Abstract:

The secretion of antibodies into the gut following oral and intraperitoneal immunization was comparatively investigated. After oral as well as intraperitoneal immunization of mice with sheep red cells SE we found agglutinating antibodies of the 7S and 11S type in the gut secret. After intravenous injection passive immunization of anti-SE-gammaglobulin only low quantities of antibodies secreted out of the serum in the gut. Active intraperitioneal immunization resulted in higher antibody titers in the secret than immunization with threefold quantities of antigen. The effect of local administration of antigen upon immune reaction of the mucouse membranes is discussed. It is suggested that intraperitoneal as well as oral antigen application represent local forms of immunization for the lamina propria of the gastrointestinal-tract. Modified author abstract

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE