Ueber die Wirkung von Nystatin Gegen Candida Albicans im Proteolyse-Kulurfiltrat von Candida Albicans (About the Effect of Nystatin on Candida Albicans in the Proteolysis-Culturefiltrate of C. Albicans),
ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)
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The effect of nystatin against 30 strains of C. albicans has been tested in SABOURAUDs glucose broth as well as in the proteolysis-culturefiltrate of C. albicans, strain CBS 2730. Nystatin caused a stronger inhibition in proteolysis-culturefiltrate, having an initial pH of 6,0 than in SABOURAUDs glucose broth. The minimum inhibitory concentration of nystatin in proteolysis-culturefiltrate initial pH 3,5 was 100 unitsml for 15 strains and exceeding 100 unitsml for 5 strains. In SABOURAUDs glucose broth having the same initial pH, on the other hand, the minimum inhibitory concentration of nystatin was 25 unitsml for 17 strains and 12,5 unitsml for 12 strains. These results are of interest because optimal proteolysis by C. albicans in vitro occurs at a pH of approx. 3,5.