Combined Use of Interferon and Certain Styrylquinolines in Cell Culturing and in Experimental Arbovirus Infection Infection
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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The effect of the combined use of interferon and certain preparations of the styrylquinoline group on the reproduction of the viruses of Venezuelan equine encephalomyelitis VEE and Western equine encephalomyelitis WEE was studied. The preparations R-29P, R-42P and R-43P in combination with interferon in chicken embryo fibroblast cultures showed antiviral activity in a reduction of VEE and WEE virus titers by 6.6 and 7.5 log, respectively. Preliminary treatment of white mice with WEE virus, followed by two injections of R-42, led to increased protective antiviral activity and to prevention of development of the disease in 60-75 of the test animals, depending on the infectious dose.