Metabolic Effects of Monomethyl Hydrazine
Final rept. 1 Jan 1971-31 Dec 1972
OREGON STATE UNIV CORVALLIS SCIENCE RESEARCH INST
Pagination or Media Count:
The pattern of utilization of glucose specifically labeled with 14C at various carbon atoms by animals under subacute Metabolic Effects of Monomethyl Hydrazine MMH intoxication indicates that MMH produces a profound depression of glycolytic metabolism, possibly associated with failure of insulin release. Functionally, the deficit appears to be located immediately prior to formation of triose phosphate, although assay of enzyme activity shows that pyruvate kinase is also severely inhibited. Blood glucose levels in intoxicated rats with adequate glucose available but low glycogen rise precipitously and remain high for as long as 12 hours. Similar but less extensive increase was induced in absolutely fasted rats. The observed metabolic defects respond to pyridoxine HCl and to insulin therapy.
- Anatomy and Physiology