Pathophysiological Response of the Canine Species in 'Escherichia coli' Endotoxemia
OKLAHOMA UNIV FOUNDATION INC OKLAHOMA CITY MEDICAL CENTER RESEARCH AND DEVELOPMENT OFFICE
Pagination or Media Count:
The pathophysiological effects of short-term septicemia and shock have been well documented in previous studies. The purpose of this research was to induce septicemia in a group of dogs with the use of live Escherichia coli organisms and extend the study over a 12-hour period of time. This period of time was in contrast to most previous studies which were conducted over a shorter time span. The live organisms were used rather than purified endotoxin so as to more closely approximate the clinical entity as seen in the human patient. In summation, there was a correlation of hemodynamic measurements, clinical pathological alterations and morphological changes of the lung during a 12-hour study of septicemic animals.
- Medicine and Medical Research