Evaluation of the Role of a Myocardial Depressant Factor in Shock
OKLAHOMA UNIV FOUNDATION INC OKLAHOMA CITY MEDICAL CENTER RESEARCH AND DEVELOPMENT OFFICE
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The purpose of the present study was to evaluate the role of a myocardial depressant factor MDF in shock. Experiments were carried out in dogs subjected to either splanchnic arterial occlusion SAO shock or endotoxin shock after pancreatectomy. An isolated heart monitored substances in blood released during SAO shock or was subjected to endotoxin shock during a 4-5 hour period. Afterload and cardiac output of the isolated heart were controlled or maintained constant. Results demonstrated normal myocardial performance of the test heart receiving blood from the splanchnic region after release of occlusion clamps during early and late phases of SAO shock. Hearts were observed to fail in animals acutely pancreatectomized and administered endotoxin while pancreatectomized controls exhibited normal myocardial performance. Pancreatectomy did not lessen the degree of heart failure after endotoxin. These findings fail to lend support for the MDF hypothesis but suggest a role of peripheral vascular factors in the pathogenesis of SAO shock and ascribe to as yet unknown mechanisms the precipitation of myocardial failure in endotoxin shock.
- Anatomy and Physiology
- Medicine and Medical Research