Experimental Evaluation of Woven Polylactic Acid, Polyester Tubes as Tracheal Protheses.
Annual summary rept. no. 2, 1 Aug 72-1 Aug 73,
LANKENAU HOSPITAL PHILADELPHIA PA
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The experimental thesis that a mechanically suitable tube for tracheal replacement could be fashioned using a mixture of a permanent, non-reactive fiber and a biodegradable fiber was examined by subcutaneous implantation of tubes prepared for use as tracheal prostheses. Histologic comparison of tissue response and rate of degradation of PLA vs. polyester was made. In these experiments it was evident that PLA fibers increase in size two or three-fold prior to eventual dissolution after approximately six months. In addition, increased tissue reactivity is apparent with greater fibroplasia in PLA specimens as compared with woven polyester. These findings indicate that a probability of lumen obstruction exists if PLA is used in prosthetic tubes used in biological systems. Modified author abstract
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